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Books that started significant movements
or new awareness in the 20th century:

The well of loneliness, by Radcliffe Hall, 1928
(Lesbianism)
Silent Spring, by Rachel Carson 1962
(Pollution)
Unsafe at any speed, by Ralph Nader 1965
(vehicular safety)
Situation Ethics: The New Morality, by Joseph Fletcher 1966
(Moral responsibility)
And the band played on, by Randy Shilts 1987
(AIDS)
Final Exit, by Derek Humphry 1991
(euthanasia)

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